Thyroid dysfunction stands as the most prevalent endocrine disorder in individuals with Down syndrome, particularly showcasing both clinical and subclinical hypothyroidism. The objective of this study was to analyze the appropriateness of the replacement therapeutic approach by identifying the TSH and FT4 values that can be considered normal in these patients.Is There an Adequate Therapeutic Approach to Thyroid Pathology in Patients with Down SyndromeSource: Murillo-Llorente et al.