Individuals with Down syndrome (DS) are living longer than they used to. This trend has led to a heightened prevalence of DS-associated Alzheimer’s disease (DS-AD) in the adult DS population. Information about the impacts of longer lives and increased DS-AD prevalence is lacking. This information is needed to inform both investment in research development programs for new treatments for DS-AD and policies related to health care and caregiving for aging adults with DS. To begin addressing the knowledge gap, RAND developed a multistate population simulation and projection model to study trends in DS-AD and the associated impact on caregiving. The study was funded by the LuMind IDSC Foundation, the Alliance for Aging Research, BrightFocus Foundation, and the National Down Syndrome Society.Modeling the Impact of Research Investment on Down Syndrome-Associated Alzheimer’s DiseaseSource: Weden et al.