Interventional
Not yet recruiting
Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 2)
Gender: all
Age: 6 Years to 18 Years
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Clinical Trials List
Observational
Not yet recruiting
OHRQoL and Parental Perception in a Group of Children and Adolescents With Down Syndrome: A Cross
Gender: all
Age: 6 Years to 14 Years
Trial Description
The aim of the study is to evaluate Oral Health related quality of life of children and adolescents with down syndrome and Parental Perception, knowledge and Attitude on oral health conditions of children and adolescents with down syndrome.Interventional
Not yet recruiting
A Study of ACI-24 in Adults With Down Syndrome
Gender: all
Age: 40 Years to 50 Years
Trial Description
This study is a prospective multicenter, placebo-controlled, double-blind, randomized study to assess the effect of one dose ACI-24 versus placebo over a 74-week treatment period and 26-week safety follow-up period.Observational
Not yet recruiting
Pulmonary Health in Children With Down Syndrome
Gender: all
Age: 3 Years to 18 Years
Trial Description
The goal of the study is to learn more about tests that can assess lung health in children with Down syndrome.Interventional
Not yet recruiting
Medications for Obstructive Sleep Apnea In Children With Down Syndrome
Gender: all
Age: 6 Years to 17 Years
Trial Description
This is a randomized, double blind, cross-over study of the combination of atomoxetine and oxybutynin (ato-oxy) in children with DS and OSA documented by polysomnography (PSG). Participants will receive high dose ato-oxy for four weeks as well as low dose ato-oxy for four weeks in random order. During the high dose ato-oxy period, participants will take 5 mg oxybutynin and 0.5mg/kg/day (max 40 mg) atomoxetine nightly for one week. Atomoxetine dose will then be increased to 1.2 mg/kg/day (max 80 mg). During the low dose ato-oxy period, participants will take 5 mg oxybutynin and 0.5mg/kg/day (max 40 mg) atomoxetine. Dosing of the study treatment will occur approximately 30 minutes prior to bedtime....